New pre-print from the lab! https://www.biorxiv.org/content/10.1101/2025.01.29.635272v1 By Abigail Strefeler et al.

New pre-print from the lab! https://www.biorxiv.org/content/10.1101/2025.01.29.635272v1 By Marcell Harhai et al.

We are looking for a postdoctoral associate to study nucleotide metabolism in physiology and cancer in vivo! Have a look at the job ad. Application will only be considered from the UNIL platform.

This image by Emeline Recazens illustrates our recent publication led by Mads Foged on the cytosolic role of N6AMT1 in mitochondrial gene expression and innate immunity

New preprint from the lab! biorxiv.org/cgi/content/short/2024.07.02.601698v1 By Miriam Lisci et al.

Our work on uridine metabolism is featured in the Cancer Metabolism 2.0 collection at Springer Nature on the occasion of the 100th anniversary of the Warburg effect! https://www.nature.com/collections/djjgbfahdf

New preprint from the lab! biorxiv.org/cgi/content/short/2024.07.02.601698v1 By Mads Foged et al.  

PhD students Abigail Strefeler and Joan Blanco-Fernandez teamed up to discuss how nucleosides - and nucleic acids! - can be used as energy sources, notably in cancers and in immunity. PDF

It was a pleasure to share my story in an interview with the Faculty of Biology & Medicine at UNIL (in French): https://news.unil.ch/display/1708338051461

In a "Career Pathways" article in Nature Metabolism Alexis discusses how he became a biologist and his career so far. PDF.

In a "Voices" article in Molecular Cell Alexis shares his experience finishing his postdoc, moving to another continent and opening his lab during the COVID-19 pandemic. PDF

Welcome Lilit Petrosyan and Anaïs Senn! Lilit and Anaïs are master students from the University of Lausanne and they will stay with us until the end of the year.

Our story on uridine catabolism for energy production is out in Nature Metabolism! Spearheaded by co-first authors Owen Skinner (MGH/Harvard) and Joan Blanco-Fernandez (from the lab), with Vamsi Mootha and many collaborators. PDF

In a new manuscript by Joan Blanco-Fernandez we introduce Dead-Seq, a powerful experimental method for converting negative- into positive-selection screens, compatible with CRISPR screening, ORFeome screening and more. PDF

Our group, together with Dr. Christel Tran at the Lausanne University Hospital (CHUV), was awarded a two-year interdisciplinary grant from the Research Commission at the Faculty of Biology and Medicine, University of Lausanne. With this new fund, we will develop tools to provide molecular diagnoses to patients with suspected mitochondrial disorders.

Marcell Harhai is a medical doctor from Sweden and Hungary with a strong interest in research. Marcell will develop new molecular diagnosis tools for mitochondrial disorders and investigate recently discovered mitochondrial disease genes.

Mads Møller Foged hails from Copenhagen, Denmark. During his PhD, Mads developed novel strategies for organelle isolation coupled to lipidomics.